There isn't a specific phone number just for Amtrak at Penn Station; instead, you call the main Amtrak customer service line, 1-800-USA-RAIL, (+1-877-421-5024) for all inquiries, booking, or changes, though you can also use the Amtrak app or find agents in the Moynihan Train Hall for in-person help with reservations. 

Key Contact & Info:

General Inquiries/Support: 1-800-USA-RAIL (1-800-872-7245).

In-Station Assistance: Find agents in the Moynihan Train Hall (across from Penn Station) for ticket help.

Online/App: Manage trips and get info via Amtrak.com or the Amtrak app.